DUSP16
| Proteína fosfatasa dual específica 16 | ||||
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| PDB | Buscar ortólogos: PDBe, RCSB | |||
| Identificadores | ||||
| Símbolos | DUSP16 (HGNC: 17909) KIAA1700, MGC129701, MGC129702, MKP-7, MKP7 | |||
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| Locus | Cr. 12 p13.2-p13.1 | |||
| Ortólogos | ||||
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La proteína fosfatasa dual específica 16 (DUSP16) es una enzima codificada en humanos por el gen dusp16.[1][2][3][4]
La activación de la cascada de las MAP quinasas transduce varias señales extracelulares al núcleo para inducir expresión génica, proliferación celular, diferenciación, parada del ciclo celular y apoptosis. Para que tenga lugar una activación máxima de las MAPKs, DUSP16 fosforila tanto el residuo de treonina como el de tirosina en los motivos TXY de la MAPK. Las MKPs son fosfatasas duales específicas que defosforilan el motivo TXY y por ello regulan negativamente la actividad de las MAPKs.[4]
Interacciones
La proteína DUSP1 ha demostrado ser capaz de interaccionar con:
Referencias
- ↑ a b Tanoue T, Yamamoto T, Maeda R, Nishida E (Jul de 2001). «A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs». J Biol Chem (EE. UU.) 276 (28): 26629-39. ISSN 0021-9258. PMID 11359773. doi:10.1074/jbc.M101981200.
- ↑ a b Masuda K, Shima H, Watanabe M, Kikuchi K (Oct de 2001). «MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein». J Biol Chem (EE. UU.) 276 (42): 39002-11. ISSN 0021-9258. PMID 11489891. doi:10.1074/jbc.M104600200.
- ↑ Willoughby EA, Collins MK (Jul de 2005). «Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2». J Biol Chem 280 (27): 25651-8. PMID 15888437. doi:10.1074/jbc.M501926200.
- ↑ a b «Entrez Gene: DUSP16 dual specificity phosphatase 16».
- ↑ Willoughby, Emma A; Perkins Gordon R, Collins Mary K, Whitmarsh Alan J (Mar. de 2003). «The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK». J. Biol. Chem. (United States) 278 (12): 10731-6. ISSN 0021-9258. PMID 12524447. doi:10.1074/jbc.M207324200.
Enlaces externos
- En HomoloGene: DUSP16
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Datos: Q18046810
Multimedia: Category:Dual specificity protein phosphatase 16 / Q18046810
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