She attended Hiroshima Jogakuin Junior and Senior High School, an integrated junior and senior high school.[3] After graduating from high school, she attended Tokyo Women's Christian University to study Japanese literature. She joined Mazda to work as secretary of vice president Yoshihiro Wada in 1987 after graduating from TWCU. She married Fumio Kishida in 1988 and has three sons with him.
On 17 April 2023, Yuko Kishida traveled solo to the United States at the invitation of the First Lady, Jill Biden, making her the first spouse of a Japanese Prime Minister to have made a solo visit to the United States.[5][6][7]
During her visit, Kishida and Jill Biden planted a cherry blossom tree within the White House grounds as a symbol of the enduring friendship between the United States and Japan. Before the planting ceremony, Jill Biden gave Kishida a tour of the White House, including the Oval Office, where she had the opportunity to briefly converse with U.S. PresidentJoe Biden.[5][8]