Yoda1
Yoda1
Names
Preferred IUPAC name
2-(5-{[(2,6-Dichlorophenyl)methyl]sulfanyl}-1,3,4-thiadiazol-2-yl)pyrazine
Identifiers
ChEBI
UNII
ClC1=C(CSC2=NN=C(C3=NC=CN=C3)S2)C(Cl)=CC=C1
Properties
C 13 H 8 Cl 2 N 4 S 2
Molar mass
355.27 g/mol
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
Yoda1 is a chemical compound which is the first agonist developed for the mechanosensitive ion channel PIEZO1 . This protein is involved in regulation of blood pressure and red blood cell volume, and Yoda1 is used in scientific research in these areas.[ 1] [ 2] [ 3] [ 4] [ 5]
See also
References
^ Syeda, Ruhma; Xu, Jie; Dubin, Adrienne E.; Coste, Bertrand; Mathur, Jayanti; Huynh, Truc; Matzen, Jason; Lao, Jianmin; Tully, David C.; Engels, Ingo H.; Petrassi, H. Michael; Schumacher, Andrew M.; Montal, Mauricio; Bandell, Michael; Patapoutian, Ardem (2015). "Chemical activation of the mechanotransduction channel Piezo1" . eLife . 4 : e07369. doi :10.7554/eLife.07369 . PMC 4456433 . PMID 26001275 . S2CID 2652667 .
^ Cahalan, Stuart M.; Lukacs, Viktor; Ranade, Sanjeev S.; Chien, Shu; Bandell, Michael; Patapoutian, Ardem (2015). "Piezo1 links mechanical forces to red blood cell volume" . eLife . 4 : e07370. doi :10.7554/eLife.07370 . PMC 4456639 . PMID 26001274 . S2CID 15018525 .
^ Wang, ShengPeng; Chennupati, Ramesh; Kaur, Harmandeep; Iring, Andras; Wettschureck, Nina; Offermanns, Stefan (2016). "Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release" . Journal of Clinical Investigation . 126 (12): 4527– 4536. doi :10.1172/JCI87343 . PMC 5127677 . PMID 27797339 . S2CID 38263363 .
^ Rapetti-Mauss, Raphaël; Picard, Véronique; Guitton, Corinne; Ghazal, Khaldoun; Proulle, Valérie; Badens, Catherine; Soriani, Olivier; Garçon, Loïc; Guizouarn, Hélène (2017). "Red blood cell Gardos channel (KCNN4): The essential determinant of erythrocyte dehydration in hereditary xerocytosis" . Haematologica . 102 (10): e415 – e418 . doi :10.3324/haematol.2017.171389 . PMC 5622875 . PMID 28619848 . S2CID 31756119 .
^ Gnanasambandam, R.; Gottlieb, P. A.; Sachs, F. (2017). "The Kinetics and the Permeation Properties of Piezo Channels". In Gottlieb, Philip A. (ed.). Piezo Channels . Current Topics in Membranes. Vol. 79. Academic Press. pp. 275– 307. doi :10.1016/bs.ctm.2016.11.004 . ISBN 978-0-12-809389-4 . PMID 28728821 . S2CID 3743286 .