Shoham co-teaches two popular game theory courses on Coursera.org,[6] along with Matthew O. Jackson and Kevin Leyton-Brown, viewed by over half a million people.
Shoham initiated the AI Index, a project to track activity and progress in AI, which was launched publicly at the end of 2017.
A serial entrepreneur, in 1999 Shoham founded TradingDynamics which was sold to Ariba in 2000. In 2011 he co-founded Katango which was sold to Google in 2013. In 2014 he co-founded Timeful which was sold to Google in 2015. Following that acquisition, Shoham joined Google as principal scientist where he worked until August 2017. He later that year co-founded AI21 Labs, an AI platform company.[7]