On July 25, 2011, Negrín signed with the Chicago Cubs as an undrafted free agent and began his career with the Arizona League Cubs. He began the 2012 season with the Daytona Cubs, but was loaned to the Olmecas de Tabasco with whom he pitched in 24 games (and posted a 7–6 record and 3.12 ERA), before being returned to the Cubs organization.[1]
Negrín spent the majority of the next three seasons playing for the Triple–A Iowa Cubs. Cumulatively, he made 75 appearances for Iowa and registered a 6–11 record and 4.28 ERA with 204 strikeouts and 2 saves in 212+1⁄3 innings pitched.[2]
Leones de Yucatán
On June 23, 2015, Negrín was loaned to the Leones de Yucatán.[3] Negrín did not play in a game in 2020 due to the cancellation of the Mexican League season because of the COVID-19 pandemic.[4]
In 2022, he appeared in 18 games (17 starts) for Yucatán, but struggled to a 4-4 record and 6.78 ERA with 51 strikeouts in 82+1⁄3 innings pitched. Negrín won the Mexican League Championship with the Leones in 2022.[5]