The 10th World Soundtrack Awards were given out on 23 October 2010 in Ghent, Belgium.

Fantastic Mr. Fox by Alexandre Desplat

• Avatar by James Horner
• Where the Wild Things Are by Carter Burwell
• A Single Man by Abel Korzeniowski
• Sherlock Holmes by Hans Zimmer

Alexandre Desplat for Fantastic Mr. Fox, The Twilight Saga: New Moon, Julie & Julia, and The Ghost Writer

• Carter Burwell for Where the Wild Things Are, A Serious Man, The Kids Are All Right, The Blind Side, and Howl
• John Powell for Green Zone, How to Train Your Dragon, Knight and Day, and Ice Age: Dawn of the Dinosaurs
• Danny Elfman for The Wolfman and Alice in Wonderland
• Hans Zimmer for It's Complicated and Sherlock Holmes

T-Bone Burnett (lyrics), Ryan Bingham (music/lyrics/performer) for "The Weary Kind" in Crazy Heart

• Anika Noni Rose (performer), Randy Newman (music/lyrics) for "Almost There" in The Princess and the Frog
• Jon Thor Birgisson for "Sticks and Stones" in How to Train Your Dragon
• Kuk Harrell (lyrics), Simon Franglen (music/lyrics), Leona Lewis (performer), James Horner (music/lyrics) for "I See You" in Avatar
• Paul McCartney for "(I Want to) Come Home" in Everybody's Fine

A Single Man by Abel Korzeniowski

• The Book of Eli by Atticus Ross
• Skin by Hélène Muddiman
• District 9 by Clinton Shorter
• The Last Station by Sergei Yevtushenko

• A Single Man by Abel Korzeniowski

• Karzan Mahmood

• John Barry

• World Soundtrack Awards 2010 at IMDb
• 10th World Soundtrack Awards