Wolff is a variant of the Wolf surname which is derived from the baptismal names Wolfgang or Wolfram.

• Albert Wolff (disambiguation), several people
• Alex Wolff, American actor
• Alexander Wolff, American writer
• Alexander Wolff (soldier), (1788–1863), British officer who served under the Duke of Wellington
• Andreas Wolff (born 1991), German handball player
• Auguste Wolff (1821–1887), French piano maker

• Betje Wolff (1738–1804), Dutch writer
• Bernard Wolff (1811–1879), German media mogul
• Bernard Wolff Beffie (1872–1943), Dutch chess master and dermatologist
• Beverly Wolff (1928–2005), American mezzo-soprano
• Bobby Wolff (born 1932), American bridge player

• Carl Gustaf Wolff, a prominent Finnish shipowner and businessman
• Caspar Friedrich Wolff (1734–1794), founder of embryology
• Christian Wolff (disambiguation), several people
• Christoph Wolff (born 1940), German-born musicologist
• Cynthia Griffin Wolff (born 1936), American literary historian

• Ed Wolff (actor) (1907–1966), American actor
• Edward Wolff (born 1946), American economist
• Elsie Wolff Van Sandau, British suffragette, see Mathilde Wolff Van Sandau
• Enrique Wolff (born 1949), Argentine football player
• Ernst Victor Wolff (1886–1961), German-born classical pianist and harpsichordist

• Francis Wolff, photographer and the founder of Blue Note Records
• Francis Wolff (philosopher) (born 1950), French philosopher, see List of French philosophers
• Frank Wolff (disambiguation), several people
• Franklin Merrell-Wolff (1887–1985), an American mystical philosopher
• Freddie Wolff (1910–1988), British sprinter

• Geoffrey Wolff (born 1937), American writer

• Hans Wolff (disambiguation), multiple people
• Hellmuth Wolff (disambiguation), multiple people
• Heinz Wolff (1928–2017), German-British scientist and television and radio presenter
• Henny Wolff (1896–1965), German soprano concert singer and voice teacher
• Henry Drummond Wolff (1830–1908), English diplomat

• Iris Wolff (born 1977), German writer
• Irving Wolff (1894–1982), American physicist

• J. Scott Wolff (1878–1958), American politician from Missouri
• James H. Wolff (1847–1913) American lawyer, war veteran, civil rights activist
• Johann Friedrich Wolff (1778–1806), German botanist
• Jonathan Wolff (disambiguation), several people
• Josh Wolff (born 1977), American soccer player
• Joseph Wolff (1795–1862), Jewish Christian missionary from Germany
• Joseph C. Wolff (1849–1896), New York politician
• Julius Wolff (disambiguation), several people
• Johannes "Hans" Hermann Wolff (1896–1976), German Engineer

• Karin Wolff (1959), German politician
• Karl Wolff (1900–1984), high-ranking member of the Schutzstaffel
• Karl Felix Wolff (1879–1966), self-taught folklorist of the South Tyrol
• Kurt Wolff (disambiguation), several people

• Lester L. Wolff (1919–2021), American politician
• Lewis Wolff (born 1935), American billionaire real estate developer
• Louis Wolff (1898–1972), American cardiologist

• Maritta Wolff (1918–2002) American novelist
• Mathilde Wolff Van Sandau (1843–1926), British suffragette
• Matthew Wolff (born 1999), American golfer
• Michael Wolff (disambiguation), several people
• Milton Wolff (1915–2008), commander of the Lincoln Battalion

• Nat Wolff (born 1994), American actor
• Nelson Wolff (born 1940), American politician
• Noah Wolff (1809–1907), German industrialist and community leader

• Otto Herbert Wolff (1920–2010) German-British paediatrician

• Pat Wolff American pediatrician
• Patrick Wolff (born 1968), American chess player
• Peter Wolff (disambiguation), several people

• Richard Wolff (disambiguation), several people
• Rikard Wolff (1958–2017), Swedish actor
• Robert Wolff (disambiguation), several people
• Roger Wolff (1911–1994), American baseball player

• S. Drummond Wolff (1916–2004), English organist, mainly active in America
• Salomon (Sam) de Wolff (1878–1960), Dutch economist and politician
• Sam Wolff (born 1991), American baseball player
• Sheldon Wolff (1928–2008), American radiobiologist and cytogeneticist
• Sheldon M. Wolff (1930–1994), American physician and immunologist
• Stefan Wolff, German political scientist and professor living in the UK
• Sula Wolff (1924–2009), prominent British child psychiatrist
• Susie Wolff (born 1982), British racing driver

• Theodor Wolff (1868–1943), German journalist
• Thomas Wolff (1954–2000), American mathematician
• Tobias Barrington Wolff (born 1970), American professor of law
• Tobias Wolff (born 1945), American writer
• Toto Wolff (born 1972), Austrian racing driver and investor

• Virginia Euwer Wolff (1882–1941), English writer
• Victoria Wolff (1903–1992), German born American writer and screenwriter.

• Werner Wolff (disambiguation), several people
• William Wolff (1927–2020), German-British journalist and rabbi

• Wolff v. McDonnell, a U.S. Supreme Court case