William Worthington may refer to:

• William Worthington (actor) (1872–1941), American silent film actor and director
• William Worthington (priest) (1703–1778), Anglican priest and theological writer
• William Barton Worthington (1854–1939), British civil engineer
• William Grafton Delaney Worthington (1785–1856), American lawyer, judge, and politician
• William H. Worthington (1828–1862), American farmer, lawyer, and military officer
• William Jackson Worthington (1833–1914), American politician
• William Chesley Worthington (1903–2002), editor of The Providence Journal and editor of the Brown Alumni Monthly

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