William Houghton may refer to:

• William Houghton (bishop) (died 1298), Roman Catholic Archbishop of Dublin, Ireland
• William Houghton (naturalist) (1828–1895), author of British Fresh-Water Fishes (1879)
• William Houghton (American football) (1908–2001), American football coach
• William Henry Houghton (1887–1947), president of the Moody Bible Institute
• William Stanley Houghton (1881-1913), British playwright
• William Vasey Houghton (1921–2001), Australian politician
• William Houghton (cricketer) (born 1955), Zimbabwean cricketer

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