William Giles and Bill Giles may refer to:

• Bill Giles (American football) (1932–1998), head football coach at Chadron State College Fort Hays State University
• Bill Giles (baseball) (William Yale Giles, born 1934), longtime Philadelphia Phillies executive and part owner
• Bill Giles (meteorologist) (William George Giles, born 1939), meteorologist and television presenter
• William Giles (colonial manager) (1791–1862), CEO of the South Australia Company, 1841–1860, and member of the South Australian colonial legislature
• William Giles (Oz), fictional character on HBO's prison drama Oz, played by Austin Pendleton
• William B. "Buck" Giles (1903–1985), American baseball player
• William Branch Giles (1762–1830), American statesman
• William Fell Giles (1807–1879), U.S. Representative from Maryland
• William Henry Giles Kingston (1814–1880), writer of tales for boys
• William L. Giles (1911–1997), president of Mississippi State University, 1966–1976

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