William Caine may refer to:

• William Caine (Hong Kong) (1799–1871), Colonial Secretary and acting Governor of Hong Kong
• William Sproston Caine (1842–1903), British politician and Temperance advocate
• William Caine (author) (1873–1925), British novelist
• L. William Caine, college football coach

• William Cain (disambiguation)
• William Kane (disambiguation)
• Caine (surname)

Topics referred to by the same term

This disambiguation page lists articles about people with the same name.
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