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Wendy Sarah Garrett
Wendy Sarah Garrett
	Garrett speaks at the National Human Genome Research Institute in 2013
Alma mater	Yale University
	Scientific career
Institutions	Harvard University Medical School ; Dana-Farber Cancer Institute ; Harvard T.H. Chan School of Public Health
Thesis	The regulation of endocytosis in developing dendritic cells (2001)

Wendy Sarah Garrett is an American microbiologist who is the Irene Heinz Given Professor of Immunology and Infectious Diseases at the Harvard Chan School of Public Health. She holds a joint position in the Departments of Medicine at Harvard Medical School.

Early life and education

Garrett was a medical student at Yale University.^[1] She remained there for her doctoral research, where she studied the regulation of endocytosis in the development of dendritic cells.^[2] She was a Research Fellow the Dana-Farber Cancer Institute and postdoctoral researcher at the Harvard University Medical School.^{[citation needed]}

Research and career

Garrett investigates host-microbiota interactions in health and disease.^[3] She is interested in the interplay between the gastrointestinal immune system and the gut microbiome, particularly in the context of inflammatory bowel disease and colorectal cancer.^[4] She has shown that the gut microbiota influence both innate and adaptive immune populations, contributing to immune homeostasis and disease. She identified specific microbial species, pathways, and metabolites that impact health and disease states.^{[citation needed]}

Garrett has investigated the microbes and immune cells that play a role in carcinogenesis and intestinal homeostasis. She has developed approaches that combine meta-omics, microbiology, cellular immunology, biochemistry, cell biology, and cancer biology. To uncover fundamental biological mechanisms and apply findings to precision medicine, Garrett combines mouse models, human specimens, and mammalian and bacterial cells, as well as in vivo and in vitro model systems.^{[citation needed]}

Garrett has shown that Fusobacterium nucleatum, a microbe of the mouth, is abundant in colon tumors.^[5]^[6] She believes that this could be an early indicator of carcinogenesis.^[5]

In 2017, Garrett established a microbiome biobank at Harvard.^[7] The biobank is the most comprehensive collection of specimens in the world, using samples of people from the Nurses' Health Study and other long-term cohort studies. In 2020 she was elected to the American Society for Clinical Investigation, who awarded her the Marian W. Ropes, MD Award in 2023.^[1]