State Route 21 may refer to:

• State Route 21 (Virginia 1918-1933), now U.S. Route 211 and its former extension along U.S. Route 29 to Washington, D.C.
• U.S. Route 21 (Virginia), from 1926

• Virginia's 21st congressional district (VA 21)

This disambiguation page lists articles associated with the title Virginia State Route 21.
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