Metropolitan Vikentije, the son of daskal (teacher) Lav Popović, was born in Janjevo in the Lipljan municipality of southeastern Kosovo and took monastic vows in the Patriarchal Monastery of Peć. Like all of the early metropolitans of Karlovci, Vikentije also spent his early career in the Patriarchate of Peć where he received his education.[3]
In January 1708. he was elected as Eastern Orthodox Bishop of Buda (modern Budapest, capital of Hungary). Upon election to the metropolitan throne in 1713, he initially resided in the Monastery of Krušedol, that was plundered during the Austro-Turkish War (1716-1718), forcing him to transfer metropolitan residence to Sremski Karlovci, thus creating the base for change of title from Metropolitanate of Krušedol to Metropolitanate of Karlovci.[4]