Van Diepen received a B.A. degree in international studies from American University and a S.M. degree from the Massachusetts Institute of Technology.[1] He began his career in the Bureau of Intelligence and Research as a Soviet military analyst, and later held positions managing chemical and biological weapons nonproliferation initiatives, and ballistic missile threat reduction programs, for the U.S. State Department.[1] In 2006 he moved to the Office of the Director of National Intelligence, returning to the State Department in 2009 as Principal Deputy Assistant Secretary of State for International Security and Nonproliferation.[1]
Until late 2011, Van Diepen spent two years as acting Assistant Secretary of State for International Security and Non-Proliferation, but was never nominated to the post on a permanent basis due to doubts by the Obama presidency as to whether the United States Senate would confirm his appointment owing to continuing concerns by some Republican senators over the 2007 NIE.[4] While acting as Assistant Secretary of State he confronted Ukrainian officials over allegations they had been supplying South Sudan with T-72main battle tanks which, according to diplomatic cables, led to a "commotion on the Ukrainian side".[5]