Originally from Hinganghat in Vidarbha, Maharashtra, Mhade is married to Anant Mhade in hinganghat, and the mother of a girl, Aastha Mhade.[2] She was a contestant in the reality show Bigg Boss Marathi in 2019.
Vaishali sung a title track for the Marathi daily soap, 'Kulvadhu', a popular show aired on Zee Marathi.She has also sung for Shridhar Phadke in his album Sangeet Manmohee Re. At the 2009 Nagpur International Marathon she was a special invitee along with Olympics gold medalist Abhinav Bindra.[4]She made her Bollywood singing debut with the song Hum Tum in the movie Damadamm! (2011). It was a duet track between Mhade and Himesh Reshammiya. She sang at Lord Buddha live T.V. show. She has recently given playback for the duet song "Pinga" along with Shreya Ghoshal for the movie Bajirao Mastani.[5] The song features Deepika Padukone and Priyanka Chopra. She has also lent her voice for 'Fitoori' in the same film. The movie is produced by Sanjay Leela Bhansali and was released on 19 December 2015. Vaishali sung a title track for the Marathi daily soap, "Honar Soon Mi Hya Gharchi", a popular show aired on Zee Marathi. Vaishali sung a title track for the Marathi daily soap, "Majhya Navaryachi Bayko", a popular show aired on Zee Marathi. Recently she lend her voice in movie Kalank along with Shreya Ghoshal in song 'Ghar More Pardesiya'. Vaishali was one of the Celebrity participants of this Marathi singing Reality Show. She quit the show on 21 February 2018 telecast to pursue PHD and MPhil.