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VSV-G

VSV-G is the envelope glycoprotein of vesicular stomatitis virus (VSV), a rhabdovirus that infects livestock. It is the only envelope protein encoded by VSV and mediates VSV virions' attachment to host cells and the fusion of their membrane with the membrane of their host.[1] VSV-G is widely used for viral psuedotyping, due to its broad host cell tropism.[2]

Function

VSV-G binds to the LDL-Receptor and other members of the LDL-Receptor Family, which serve as receptors for VSV.[3]

Uses in Research

Lentiviral and retroviral vectors pseudotyped with VSV-G are frequently used in cell biology research to introduce genes to broad range of mammalian cell types.[2]

References

  1. ^ Kim, Irene S.; Jenni, Simon; Stanifer, Megan L.; Roth, Eatai; Whelan, Sean P. J.; van Oijen, Antoine M.; Harrison, Stephen C. (2017-01-03). "Mechanism of membrane fusion induced by vesicular stomatitis virus G protein". Proceedings of the National Academy of Sciences of the United States of America. 114 (1): E28–E36. Bibcode:2017PNAS..114E..28K. doi:10.1073/pnas.1618883114. ISSN 1091-6490. PMC 5224367. PMID 27974607.
  2. ^ a b Arduini, Ariana; Katiyar, Harshita; Liang, Chen (2025-05-31). "Progress in Pseudotyping Lentiviral Vectors Towards Cell-Specific Gene Delivery In Vivo". Viruses. 17 (6): 802. doi:10.3390/v17060802. ISSN 1999-4915. PMC 12197403. PMID 40573393.
  3. ^ Nikolic, Jovan; Belot, Laura; Raux, Hélène; Legrand, Pierre; Gaudin, Yves; A. Albertini, Aurélie (2018-03-12). "Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein". Nature Communications. 9 (1): 1029. Bibcode:2018NatCo...9.1029N. doi:10.1038/s41467-018-03432-4. ISSN 2041-1723. PMC 5847621. PMID 29531262.
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