PROFILPELAJAR.COM

User:ASeigel/sandbox

COMPASS complex

Since it was first identified in 2001, other members of the COMPASS family of methylases with different functions have been discovered, in particular in humans.[1] Complex Proteins Associated with Set1, also known as COMPASS, is a conserved protein complex playing a major role as a H3K4me3 methylase in eukaryotes.[2]



The Compass complex, or similar protein complexes, have been identified in species ranging from single celled fungi to humans.[3] They play an important regulatory role in many invaluable biological processes including DNA repair, the progression of the cell cycle and transcription through the methylenation of histone lysines.[3]



The COMPASS complex is an example of a trithorax-group protein.[1] The MILL1/SET domain associated with the COMPASS complex have crystal structure.[3]



References

  1. Shilatifard, Ali (2012). "The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis". Annual review of biochemistry. 81: 65–95. doi:10.1146/annurev-biochem-051710-134100. ISSN 0066-4154. PMC 4010150. PMID 22663077.
  2. Miller, Trissa; Krogan, Nevan J.; Dover, Jim; Erdjument-Bromage, H.; Tempst, Paul; Johnston, Mark; Greenblatt, Jack F.; Shilatifard, Ali (2001-11-06). "COMPASS: A complex of proteins associated with a trithorax-related SET domain protein". Proceedings of the National Academy of Sciences of the United States of America. 98 (23): 12902–12907. doi:10.1073/pnas.231473398. ISSN 0027-8424. PMID 11687631.
  3. Takahashi, Yoh-hei; Westfield, Gerwin H.; Oleskie, Austin N.; Trievel, Raymond C.; Shilatifard, Ali; Skiniotis, Georgios (2011-12-20). "Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human". Proceedings of the National Academy of Sciences. 108 (51): 20526–20531. doi:10.1073/pnas.1109360108. ISSN 0027-8424. PMC 3251153. PMID 22158900.
  1. ^ a b Shilatifard, Ali (2012). "The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis". Annual review of biochemistry. 81: 65–95. doi:10.1146/annurev-biochem-051710-134100. ISSN 0066-4154. PMC 4010150. PMID 22663077.
  2. ^ Miller, Trissa; Krogan, Nevan J.; Dover, Jim; Erdjument-Bromage, H.; Tempst, Paul; Johnston, Mark; Greenblatt, Jack F.; Shilatifard, Ali (2001-11-06). "COMPASS: A complex of proteins associated with a trithorax-related SET domain protein". Proceedings of the National Academy of Sciences of the United States of America. 98 (23): 12902–12907. doi:10.1073/pnas.231473398. ISSN 0027-8424. PMID 11687631.
  3. ^ a b c Takahashi, Yoh-hei; Westfield, Gerwin H.; Oleskie, Austin N.; Trievel, Raymond C.; Shilatifard, Ali; Skiniotis, Georgios (2011-12-20). "Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human". Proceedings of the National Academy of Sciences. 108 (51): 20526–20531. doi:10.1073/pnas.1109360108. ISSN 0027-8424. PMC 3251153. PMID 22158900.{{cite journal}}: CS1 maint: PMC format (link)

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.