Search Results: Upf1
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UPF1
Jumat, 2026-02-06 03:53:41Up-frameshift suppressor 1 homolog) is a protein that in humans is encoded by the UPF1 gene. This gene encodes a protein that is part of a post-splicing multiprotein...
Click to read more »Decapping complex
Kamis, 2025-10-02 22:37:47the helicase Dhh1, the exonuclease Xrn1, nonsense mediated decay factors Upf1, Upf2, and Upf3, the LSm complex, Pat1, and various other proteins. These...
Click to read more »MRNA surveillance
Rabu, 2025-09-17 22:44:43conserved in the process of NMD. These are the Upf1/SMG-2, Upf2/SMG-3 and Upf3/SMG-4 complexes. Upf1/SMG-2 is a phosphoprotein in multicellular organisms...
Click to read more »Exon junction complex
Rabu, 2026-05-27 03:37:31between UPF2 and UPF1 forming a trimeric complex. Within this complex, UPF2 and UPF3 act cooperatively to promote ATPase and RNA helicase of UPF1. The EJC core...
Click to read more »Staufen-mediated mRNA decay
Kamis, 2026-07-16 23:13:00including UPF1 and UPF2 factors that will cleave the targeted mRNAs. SMD occurs when staufen protein binds to an mRNA and recruits SMD factors (i.e. UPF1, UPF2)...
Click to read more »Nonsense-mediated decay
Selasa, 2026-07-21 04:03:16contains a premature stop codon, then UPF1 comes into contact with UPF2 and UPF3, triggering the phosphorylation of UPF1. In vertebrates, the location of the...
Click to read more »SMG1
Jumat, 2025-07-18 01:23:43not been determined. SMG1 (gene) has been shown to interact with PRKCI and UPF1. GRCh38: Ensembl release 89: ENSG00000157106 – Ensembl, May 2017 GRCm38:...
Click to read more »SMG6
Kamis, 2025-07-17 01:38:19for why SMG6 does not form a complex with SMG5 and SMG7 when recruited by UPF1. SMG6 is broadly expressed in all human tissues. It has dual functions in...
Click to read more »STAU1
Kamis, 2026-07-30 16:19:45UPF1, which enhances its helicase activity and promotes SMD. It has been shown that STAU1 binding to UPF2 is a more stable interaction than with UPF1...
Click to read more »UPF3B
Sabtu, 2025-07-19 14:40:41been found for this gene. UPF3B has been shown to interact with UPF2 and UPF1. GRCh38: Ensembl release 89: ENSG00000125351 – Ensembl, May 2017 GRCm38:...
Click to read more »Cap binding complex
Rabu, 2023-01-04 13:29:11the mRNA decapping enzyme DCP2. A host of proteins accompany it including UPF1, UPF2, UPF3A, Dcp1, Dhh1, XRN1, and others. The decapping enzyme removes...
Click to read more »Allan Jacobson
Jumat, 2026-05-15 02:15:44and mRNA surveillance roles of conserved NMD pathway proteins including UPF1, UPF2, UPF3, and DCP2. To study the relationship between translation and...
Click to read more »Facioscapulohumeral muscular dystrophy
Selasa, 2026-08-11 17:13:15shows that DUX4 expression promotes the degradation a core NMD factor called UPF1, inhibiting the cell's ability to clear NMD-sensitive transcripts. Because...
Click to read more »UPF2
Senin, 2026-08-10 10:41:38long-term potentiation of neurons. UPF2 has been shown to interact with UPF1, UPF3A and UPF3B. GRCh38: Ensembl release 89: ENSG00000151461 – Ensembl,...
Click to read more »Staufen (protein)
Selasa, 2026-08-11 19:28:59occurs when Staufen protein binds to an mRNA and recruits SMD factors (i.e. UPF1, UPF2) that degrade the RNA molecule bound to Staufen. SMD potently affects...
Click to read more »Eukaryotic translation termination factor 1
Selasa, 2026-08-11 23:06:30This complex is composed of 4 proteins: SMG-1, Upf1, eRF1, and eRF3 (SURF). The complex is formed when Upf1 binds to SMG-1, which then clamps onto the eRF1...
Click to read more »Protein ZGRF1
Sabtu, 2025-10-04 16:30:18contains both ends outside of a membrane. ZGRF1 has related structures to Upf1, a paralog. These structures have the capability to bind zinc ions and mRNA...
Click to read more »Telomeric repeat–containing RNA
Selasa, 2026-06-02 20:53:00telomeres. Association with nonsense-mediated RNA decay (NMD) machinery such as UPF1, SMG1 and EST1A/SMG6 and members of the heterogeneous nuclear ribonucleoprotein...
Click to read more »CASC3
Kamis, 2025-07-17 22:57:04Furic L, Desgroseillers L, Maquat LE (2005). "Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay". Cell. 120 (2): 195–208...
Click to read more »Timeline of aging research
Selasa, 2026-08-11 17:12:11cellular reprogramming. UPF1 was found to decline significantly during cellular senescence. The findings suggest that the fall in UPF1 accelerates senescence...
Click to read more »GSPT1
Sabtu, 2025-07-19 12:58:51(Feb 2006). "Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA...
Click to read more »SMG5
Jumat, 2025-07-18 01:23:46Ohnishi T, Yamashita A, Kashima I, et al. (2004). "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7"...
Click to read more »Nuclear cap-binding protein complex
Rabu, 2025-09-10 04:04:35directly interacts with the nonsense-mediated decay factor, up-frameshift 1 (UPF1) which amplifies the efficiency of the whole process. The nuclear cap-binding...
Click to read more »DCP1A
Kamis, 2025-07-17 00:04:41decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This...
Click to read more »Consensus CDS Project
Jumat, 2025-12-12 09:17:13Martins, R; Faustino, P; Liebhaber, SA; Romao, L (2006). "The canonical UPF1-dependent nonsense-mediated mRNA decay is inhibited in transcripts carrying...
Click to read more »Joshua T. Mendell
Kamis, 2026-02-12 05:41:42Mendell, J.; Ap Rhys, C.; Dietz, H. (2002). "Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts". Science. 298 (5592):...
Click to read more »SMG7
Kamis, 2025-07-17 01:38:22Schell T, Anders KR, Grimson A, et al. (November 2003). "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7"...
Click to read more »Stress granule
Selasa, 2026-08-11 19:29:59Activating Kinase 1 ULK2 ULK2 Unc-51 Like Autophagy Activating Kinase 2 UPF1 UPF1 UPF1, RNA Helicase and ATPase yes UPF2 UPF2 UPF2, RNA Helicase and ATPase...
Click to read more »P-bodies
Selasa, 2026-08-11 18:58:15EDC3 EDC3 Yes EDC4 EDC4 Yes ZCCHC11 TUT4 No DHX9 DHX9 No RPS27A RS27A No UPF1 RENT1 Yes ZCCHC3 ZCHC3 No SMARCA5 SMCA5 No TOP2A TOP2A No HSPA2 HSP72 No...
Click to read more »UPF3A
Senin, 2025-12-22 04:42:43encoding different isoforms exist. UPF3A interacts with RBM8A, UPF2 and UPF1. GRCm38: Ensembl release 89: ENSMUSG00000038398 – Ensembl, May 2017 "Human...
Click to read more »List of human protein-coding genes 8
Senin, 2025-11-03 07:57:42Q9C0B0 17908 UNKL HGNC:14184; Q9H9P5 17909 UPB1 HGNC:16297; Q9UBR1 17910 UPF1 HGNC:9962; Q92900 17911 UPF2 HGNC:17854; Q9HAU5 17912 UPF3A HGNC:20332; Q9H1J1...
Click to read more »DCP2
Sabtu, 2025-07-19 12:34:282005).[supplied by OMIM] DCP2 has been shown to interact with DCP1A and UPF1. GRCh38: Ensembl release 89: ENSG00000172795 – Ensembl, May 2017 GRCm38:...
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