After shakedown and local operations along the East Coast, Ingraham commenced duties as a convoy escort in December 1941 as the Japaneseattack on Pearl Harbor drew America into World War II. In 1942, she escorted convoys between the U.S., Iceland, and the United Kingdom, bringing supplies desperately needed by the Allies to stem Hitler's advance and to take the offensive. Under constant threat from GermanU-boats, Ingraham continued her escort duty to Europe and as far south as the Panama Canal.
Ingraham was guarding Scotland-bound convoy T-20 out of Halifax. After an erroneous report of enemy submarine, convoy escorts maneuvered to locate the enemy in heavy fog.[2] On the night of 22 August, as she was investigating a collision between the destroyer Buck and a merchant vessel, Ingraham collided with the oil tanker Chemung in heavy fog off the coast of Nova Scotia and Ingraham sank almost immediately. Depth charges on her stern exploded. Only 11 men survived the collision. She was struck from the Naval Vessel Register on 11 September 1942.