USS Enterprise may refer to the following ships and other vessels:

• List of ships of the United States Navy named Enterprise
  • USS Enterprise (1775), a Continental Navy sloop captured from the British, burned to prevent recapture in 1777
  • USS Enterprise (1799), a schooner that fired the first shots in the First Barbary War
  • USS Enterprise (1831), a schooner, stationed primarily in South America to patrol and protect commerce
  • USS Enterprise (1874), a steam-powered sloop-of-war used for surveying, patrolling, and training until 1909
  • USS Enterprise (SP-790), a motorboat (1917–1919) used in World War I as a non-commissioned section patrol craft
  • USS Enterprise (CV-6), an aircraft carrier (1938–1947), the most decorated U.S. ship of World War II
  • USS Enterprise (CVN-65), the world's first nuclear-powered aircraft carrier (1961–2017)
  • USS Enterprise (CVN-80), a Gerald R. Ford-class aircraft carrier, under construction and scheduled to enter service by 2028

• USS Enterprise (BLDG 7115), a building and ship simulator at the U.S. Navy training command in Great Lakes, Illinois

• Enterprise (1776), a Continental Navy schooner, formerly a privateer, used in Chesapeake Bay as a convoy and patrol ship until 1777
• Enterprise (1814), a commercial steamboat that delivered supplies and troops during the Battle of New Orleans
• Enterprise (slave ship), a merchant vessel in the coastwise slave trade in the early 19th century
• Enterprise (yacht), a J-class yacht that won the 1930 America's Cup
• SS Flying Enterprise, an American cargo ship (1944–1952)
• USTS Enterprise (2003–2008), former name of TS Kennedy, a training ship at the Massachusetts Maritime Academy

• Enterprise (balloon), a balloon used by the Union Army during the American Civil War
• Space Shuttle Enterprise (OV-101), the first orbiter built for NASA's Space Shuttle system
• IXS Enterprise, a NASA conceptual design for an interstellar ship, c. 2013
• VSS Enterprise (2009–2014), a Virgin Galactic commercial spaceplane that broke apart during a test flight

• Starship Enterprise, a list, timeline and brief description of starships in the fictional history of Star Trek
• Enterprise (NX-01), the principal setting of Star Trek: Enterprise
• USS Enterprise (NCC-1701), the principal setting of the original Star Trek television series, Star Trek: Strange New Worlds, and the first three Star Trek feature films
• USS Enterprise (NCC-1701-A), the closing setting of the fourth Star Trek feature film and the principal setting of the fifth and sixth Star Trek feature films
• USS Enterprise (NCC-1701-B), the opening setting of the seventh Star Trek feature film
• USS Enterprise (NCC-1701-C), a starship in "Yesterday's Enterprise", an episode of Star Trek: The Next Generation
• USS Enterprise (NCC-1701-D), the principal setting of Star Trek: The Next Generation and the seventh Star Trek feature film as well as the last two episodes of Star Trek: Picard
• USS Enterprise (NCC-1701-E), the principal setting of the eighth, ninth, and tenth Star Trek feature films
• USS Enterprise (NCC-1701-F), first appeared in the Star Trek Online game in 2011 as a non-player flagship. The ship makes an appearance in the third season of the Star Trek: Picard television series.
• USS Enterprise (NCC-1701-G), first appeared in The Last Generation finale of Star Trek: Picard. Originally USS Titan (NCC-80102-A).
• USS Enterprise (NCC-1701-J), a starship referenced in "Azati Prime", an episode of Star Trek: Enterprise
• USS Enterprise (NCC-1701-M), a starship replica of NCC-1701, designated a museum ship, in the video mini-series Star Trek: Of Gods and Men (non-canon)
• ISS Enterprise (NCC-1701), a Terran starship from a "mirror universe" from the original Star Trek series as well as Star Trek: Discovery. Makes an appearance in "Mirror, Mirror"

• Enterprise (disambiguation)
• HMS Enterprise, a list of ships of the British Royal Navy

This disambiguation page lists articles associated with the title USS Enterprise.
If an internal link led you here, you may wish to change the link to point directly to the intended article.