Toxaway River Tributary to Keowee River
Location of Toxaway River mouth Show map of South Carolina Toxaway River (the United States) Show map of the United States
Location
Country	United States
State	North Carolina South Carolina
Counties	Transylvania (NC) Oconee (SC) Pickens (SC)
Physical characteristics
Source	divide between Toxaway River and Greenland Creek
• location	about 0.5 miles southeast of Cold Mountain Gap
• coordinates	35°09′03″N 082°59′21″W / 35.15083°N 82.98917°W / 35.15083; -82.98917[1]
• elevation	4,000 ft (1,200 m)[2]
Mouth	Keowee River (Lake Jocassee)
• location	Lake Jocassee
• coordinates	34°58′36″N 082°56′05″W / 34.97667°N 82.93472°W / 34.97667; -82.93472[1]
• elevation	1,108 ft (338 m)[1]
Length	21.31 mi (34.30 km)[3]
Basin size	146.73 square miles (380.0 km2)[4]
Discharge
• location	Keowee River (Lake Jocassee)
• average	508.41 cu ft/s (14.397 m3/s) at mouth with Keowee River[4]
Basin features
Progression	generally south
River system	Savannah River
Tributaries
• left	Indian Creek Panther Branch Auger Fork Toxaway Creek Rock Creek Laurel Fork Creek Devils Hole Creek
• right	Mill Creek Deep Ford Creek Bear Meadow Creek Cobb Creek Horsepasture River
Waterfalls	Toxaway Falls[2]
Bridges	Long Ridge Road, Cardinal Drive, Cold Mountain Road, NC 281

The Toxaway River is a 21.4-mile-long (34.4 km)^[5] waterway that flows south from headwaters in Transylvania County, North Carolina, into Lake Toxaway and over Toxaway Falls, after which it crosses into South Carolina and enters Lake Jocassee, the reservoir behind Lake Jocassee Dam.

In Lake Jocassee the Toxaway River is joined by the Whitewater River to form the Keowee River. The confluence is submerged beneath the waters of Lake Jocassee. Via the Keowee and Seneca rivers, the Toxaway River is part of the Savannah River watershed.

According to the Geographic Names Information System, it has also been known historically as:^[1]

• Jocassa River
• Jocassee River
• Keowee River