The program first started at the varsity level in 1958. Since then, the team has a cumulative record of 433–326, combined DI and DII. Towson has made 21 NCAA Tournament appearances.
In the 1991 NCAA tournament, under coach Carl Runk, Towson recorded their first NCAA Division I tournament victory, defeating Virginia, 14–13. That season, they went on to also defeat Princeton and Maryland, before falling to North Carolina in the championship game, 18–13. In the 2001 edition of the tournament, Towson reached the Final Four, defeating Duke and Maryland, before losing to Princeton, 11–12.
In the 2013 NCAA Division I Men's Lacrosse Championship, Towson upset NCAA tournament seed Penn State to gain the Colonial conference title, losing in the first round 16–6 to #3 seed Ohio State. Also the Tigers won 10–8 in the play-in game, followed by a close 12–10 loss to eventual finalist Notre Dame in 2015.[3]
In the 2019 season, Towson reached the #1 ranking in all three major NCAA Lacrosse polls for the first time in the school's history as a Division I school.[4]
National champion
Postseason invitational champion
Conference regular season champion
Conference regular season and conference tournament champion
Division regular season champion
Division regular season and conference tournament champion
Conference tournament champion
†NCAA canceled 2020 collegiate activities due to the COVID-19 virus.