The city was destroyed in the Vesuvius eruption of 79 AD and in 1631. The city was once the seat of important ironwork (Deriver, Dalmine), food processing and pasta industries. Today industries still active include naval, armament and pharmaceutical ones.
In the communal territory, one of the richest Roman villas has been excavated. Dating to the 1st century BC, it probably belonged to the gensPoppaea, and is known as Villa Poppaea.
Torre Annunziata is home to F.C. Savoia 1908 who play at the Stadio Giraud and currently play in Serie D of Italy's football pyramid. Their highest achievement was during the 1923–24 season where they finished Serie A runners up.
Professional footballer Ciro Immobile was born in Torre Annunziata.