McClure was drafted by the Atlanta Falcons in the seventh round of the 1999 NFL draft.[3] During training camp of his rookie season he suffered a torn anterior cruciate ligament in his right knee and missed his entire rookie season. During his second season he took over as the Falcons starting center after Calvin Collins was moved to guard. Since then he missed only one game and was the Falcons starting center from 2000 until his retirement after the 2012 season.
McClure made the first start of his career at center against the Carolina Panthers on October 29. During the 2004 postseason, McClure was part of a line that set the fourth-highest NFL postseason record with 327 rushing yards, including a Falcons record 142 yards by Warrick Dunn and an NFL record for quarterbacks with Michael Vick collecting 119 yards on the ground.[4]
McClure retired on March 13, 2013,[5] and during his retirement press conference Falcons owner Arthur Blank stated that McClure would soon join the Atlanta Falcons Ring of Honor.[6]
In July 2022, it was announced that McClure will be inducted into the team’s Ring of Honor in October.[7] On October 30, 2022 he was inducted during a home game against the Carolina Panthers.