Stanley was the son of Sir John Stanley, of Liverpool, Lathom, and Knowsley (in Huyton), Lancashire, by his wife, Elizabeth, daughter of Sir Nicholas Harington (or Haverington) of Farleton (in Melling), Lancashire.[2] He represented Lancashire in the House of Commons in 1427, 1433, 1439, 1442, 1447, 1449, 1450, 1453, 1455.
In 1424 he was attacked in his father's tower at Liverpool by Sir Richard Molyneaux, who was arrested. His family had long associations with the governance of Ireland, his grandfather Sir John Stanley, K.G., having been both Justiciar and Lord Lieutenant of Ireland (and who died there), and in 1429 he was sent to Ireland and called a Parliament in that Kingdom in 1432.
In 1437, he succeeded to the title of King of Mann upon the death of his father, John Stanley.
During the Parliament at Westminster in 1450-1 the House of Commons demanded his removal from the Royal presence with others of the Duke of Suffolk's party.[3]
William Stanley (c.1435–1495), KG, 2nd son, invested as a Knight of the Garter in 1487 by King Henry VII, but executed by that king in 1495 for treason for his alleged part in the Perkin Warbeck conspiracy.