Thomas Osborne, or variants thereof, may refer to:

• Thomas Osborne, 1st Duke of Leeds (1632–1712), English Lord High Treasurer, Lord President of the Council and MP for York
• Thomas Osborne, 4th Duke of Leeds (1713–1789), English Justice in Eyre and Cofferer of the Household
• Thomas Osborne (publisher) (1704?–1767), English publisher and bookseller

• Sir Thomas Osborne, 5th Baronet (1639–1715), Irish baronet and landowner
• Sir Thomas Osborne, 9th Baronet (1757–1821), Irish baronet and politician

Listed chronologically by year of birth

• Thomas Burr Osborne (politician) (1798–1869), U.S. Representative from Connecticut
• Thomas A. Osborne (New York politician) (1800–1877), American lawyer and politician
• Thomas O. Osborn (1832–1904), American lawyer, soldier, and diplomat
• Thomas W. Osborn (1833–1898), U.S. Senator from Florida
• Thomas A. Osborn (1836–1898), American lawyer, politician, and diplomat
• Thomas Mott Osborne (1859–1926), American prison reformer
• Thomas Burr Osborne (chemist) (1859–1929), American chemist, co-discoverer of Vitamin A
• Tom Osborne (born 1937), American college football head coach (Nebraska), and member of Congress
• Tom Osborne (American football, born 1960), American football coach (Oregon)
• Tom Osborne (engineer), American engineer who created the Green Machine which led to the Hewlett-Packard 9100A

• Thomas Osborne (Australian journalist) (c. 1806–1853), Australian journalist and politician in the Victorian Legislative Council
• Tom Osborne (Canadian politician) (born 1964), Canadian politician in Newfoundland and Labrador
• Tom Osborne (rugby union) (born 1998), Australian rugby player

• Thomas Osborne Davis (Canadian politician) (1856–1917)
• Thomas Osborne Davis (Irish politician) (1814–1845)
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