In 1947, Wofford defended the 31 white men charged with the Lynching of Willie Earle in Greenville, South Carolina.[3] The trial was highly publicized, and resulted in all of the defendants being acquitted of murder despite many of them having signed confessions.[4]
Wofford was appointed on April 5, 1956, as a Democrat to the US Senate to fill the vacancy caused by the resignation of Strom Thurmond and served from April 5, 1956, to November 6, 1956; he was not a candidate for election to fill the vacancy, and engaged in the practice of law. He was a member of the South Carolina Senate from 1966 to 1972, and changed party affiliation to Republican. He resided in Greenville, and died there in 1978; interment was in Woodlawn Memorial Park.