In Civil War-era Southern Missouri, Dr. Maggie McCullough travels to the aid of her ailing aunt, Annie, the town's madame, in the lovely community of Sweetwater. With all of the men away at war, Maggie coordinates a truce between Aunt Annie's girls and the respectable women of the town. While Maggie contemplates the love triangle that is formed with an injured Union fighter, Frank Isaacs, and a captured Confederate doctor, Captain John Cane, a demented faction of soldiers invades Sweetwater and the women must spring into action to defend their homes.