The Greene Murder Case is a murder mystery centred around the wealthy and dysfunctional Greene family, who are forced to gather annually to fulfil the stipulations of the late patriarch's will. The family is ruled by the resentful and ailing Mrs Tobias Greene (Gertrude Norman), who holds little affection for her children, Rex (Morgan Farley), Chester (Lowell Drew), and daughter Sibella (Florence Eldridge). The children despise each other, while adopted daughter Ada (Jean Arthur) is excluded from the inheritance due to her non-blood relation. The tension within the household is palpable, with suspicions surrounding Sibella's indiscreet affair with the family's doctor, Arthur Von Blon (Ullrich Haupt Sr), and rumours that Mrs Greene's infirmity may not be as severe as it seems. The Greene family's servants, including butler Sproot (Brandon Hurst), housekeeper Gertrude Mannheim (Augusta Burmeister), and devout Hemming (Marcia Harris), also harbour their own doubts. When members of the family start being murdered, District Attorney John Markham (EH Calvert) enlists the help of amateur detective Philo Vance (William Powell), who, alongside Sergeant Ernest Heath (Eugene Pallette), must sift through the animosity and hidden motives to unmask the killer.
