The four-storey hotel was built in 1828, and occupies the site of an inn previously known as the Black Bull, which was in existence as early as the fifteenth century.[2] The Black Bull was bequeathed to St Catharine's College in 1626 and rebuilt in 1828 and opened as a hotel.[3] In 1936 two "acanthus'" type posts were said to flank the stone ashlar porch of the Bull Hotel.[4]
It was one of the top hotels in Cambridge until the Second World War, when in 1941 the hotel became a centre for American serviceman.[3] Photographs taken during the war show an American flag and a British flag on the hotel. At the end of the war the American servicemen established Bull College, named after the hotel and between 1945 and 1946 the hotel functioned as a centre for Russian courses for the British Army, but then merged with St Catharine's.[5]