Terlipressin, sold under the brand name Terlivaz among others, is an analogue of vasopressin used as a vasoactive drug in the management of low blood pressure. It has been found to be effective when norepinephrine does not help. Terlipressin is a vasopressin receptor agonist.[2]
Terlipressin was approved for medical use in the United States in 2022.[2][4][5] The US Food and Drug Administration (FDA) considers it to be a first-in-class medication.[5][6]
Terlipressin is indicated to improve kidney function in adults with hepatorenal syndrome with rapid reduction in kidney function.[2]
Indications for use include norepinephrine-resistant septic shock[7] although, 2021 Surviving Sepsis Guidelines recommend against its use for adults with septic shock[8] and hepatorenal syndrome.[9] In addition, it is used to treat bleeding esophageal varices.[10]
Terlipressin is contraindicated in people experiencing hypoxia or worsening respiratory symptoms and in people with ongoing coronary, peripheral or mesenteric ischemia.[2] Terlipressin may cause fetal harm when used during pregnancy.[2]
Terlipressin is available in United States,[11] New Zealand,[12] Australia, the European Union,[13] India, Pakistan & UAE. It is sold under various brand names including Glypressin and Terlivaz.
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