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The mixed doubles event at the 2018 South American Games was held from 30 May to 2 June.

Gold	Silver	Bronze
Roberto Maytín Aymet Uzcátegui Venezuela	Tomás Farjat Melany Krywoj Argentina	Gonzalo Lama Alexa Guarachi Chile

	Quarterfinals							Semifinals							Final
								1	Roberto Maytín Aymet Uzcátegui	77	6
									Gonzalo Lama Alexa Guarachi	65	4
	Gonzalo Lama Alexa Guarachi		6	6
	Felipe Mantilla Paula Andrea Pérez		2	3
															1	Roberto Maytín Aymet Uzcátegui	77	6
																Tomás Farjat Melany Krywoj	62	0
	Arklon Huertas Camila Soares		65	4
	Tomás Farjat Melany Krywoj		77	6
									Tomás Farjat Melany Krywoj	6	6				Third place
								2	Federico Zeballos Noelia Zeballos	1	2
		Iván Endara Mell Reasco	4	5												Gonzalo Lama Alexa Guarachi	4	4
	2	Federico Zeballos Noelia Zeballos	6	7											2	Federico Zeballos Noelia Zeballos	0	2

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• Draw