In 2005, Palmore began her career at the NIH as a staff clinician in the NIAID laboratory of clinical infectious diseases. She became deputy hospital epidemiologist in the NIH Clinical Center in 2007, focused on optimizing patient safety through prevention of hospital-acquired infections. In 2013, along with Dr. Julie Segre and other NIH colleagues, Palmore was awarded a Samuel J. Heyman Award for Federal Employee of the Year for her work stopping a deadly epidemic of a multi-drug resistant strain of Klebsiella pneumoniae through genomic sequencing.[2][3] She was promoted to hospital epidemiologist in 2014. In 2021, she became a Professor of Medicine in the Division of Infectious Diseases and Hospital Epidemiologist at George Washington University School of Medicine and Health Sciences[1] In 2023, she returned to the NIAID to become a Senior Medical Advisor.