In 2005, D'Souza made her cinematic debut in The Angrez (2005) which was a Tollywood film which only released in some parts of Hyderabad and did become a super hit film locally, and since it didn't release in many theaters she was not well known after this picture.[4]
She was cast in Yash Raj FilmsMere Brother Ki Dulhan opposite Ali Zafar; it was considered as a hit. Fans enjoyed her performance in this film and she became very well known. She also acted in Mujhse Fraaandship Karoge, a story based on Facebook, which received positive reviews.