She specialises in Baroque music, but also pursues projects of contemporary music.[4] She recorded with the jazz pianist Michael Wollny the album Wunderkammer which was awarded the Echo Jazz in the category piano album in 2010. She recorded a sequel, Wunderkammer XXL, with Wollny and the hr-Bigband which was awarded the Echo Jazz in the category big band. She played harpsichord and celesta with Wollny at the Jazzfest Bonn 2014.[5]
In 2011, she played works by Bach on the harpsichord at the BaroqueChristophoruskirche in Wiesbaden-Schierstein, as part of the Rheingau Musik Festival.[6] In 2012, Halperin recorded Lieder by Haydn, Mozart, Schubert and Brahms with her husband, the countertenor Andreas Scholl, titled Wanderer.[3] The reviewer of a similar program at Wigmore Hall noted in The Guardian that she "proved to be a wonderfully subtle accompanist and a performer of real distinction", offering piano works by Mozart and Brahms in addition to the songs.[7] In 2016 she published an album with music by Erik Satie on the occasion of the 150th anniversary of his birth, played on different keyboard instruments including, besides piano and harpsichord, hammond organ and Wurlitzer piano.[2]