Takeshi Saito may refer to:

• Takeshi Saito (footballer) (斉藤 武志, born 1979), Japanese footballer
• Takeshi Saito (ice hockey) (齊藤 毅, born 1981), Japanese ice hockey player
• Takeshi Saito (mathematician) (斎藤 毅, born 1961), Japanese mathematician
• Takeshi Saito (musician) (斎藤 毅, born 1959), Japanese violinist

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