PROFILPELAJAR.COM

TNIP1
Identifiers
Aliases	TNIP1, ABIN-1, NAF1, VAN, nip40-1, TNFAIP3 interacting protein 1
External IDs	OMIM: 607714; MGI: 1926194; HomoloGene: 31355; GeneCards: TNIP1; OMA:TNIP1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	151,093,577 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	54,853,743 bp
RNA expression pattern
	Top expressed in
	blood; ; muscle of thigh; ; epithelium of colon; ; apex of heart; ; gastrocnemius muscle; ; glutes; ; bone marrow cells; ; granulocyte; ; cartilage tissue; ; spleen;
	Top expressed in
	decidua; ; left colon; ; temporal muscle; ; granulocyte; ; triceps brachii muscle; ; muscle of thigh; ; mesenteric lymph nodes; ; sternocleidomastoid muscle; ; jejunum; ; pyloric antrum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; mitogen-activated protein kinase binding; identical protein binding; polyubiquitin modification-dependent protein binding;
Cellular component	intracellular anatomical structure; nucleoplasm; nucleus; cytosol; cytoplasm;
Biological process	leukocyte cell-cell adhesion; defense response; glycoprotein biosynthetic process; negative regulation of viral genome replication; modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade; positive regulation of inflammatory response; inflammatory response; protein biosynthesis; negative regulation of ERK1 and ERK2 cascade; MyD88-dependent toll-like receptor signaling pathway; regulation of inflammatory response; negative regulation of I-kappaB kinase/NF-kappaB signaling; protein deubiquitination; positive regulation of transcription by RNA polymerase II; cellular response to lipopolysaccharide; positive regulation of protein deubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	10318
	57783
	ENSG00000145901
	ENSMUSG00000020400
	Q15025
	Q9WUU8
NM_001252385; NM_001252386; NM_001252390; NM_001252391; NM_001252392;
	NM_001252393; NM_001258454; NM_001258455; NM_001258456; NM_006058; NM_001364486; NM_001364487
	NM_001199275; NM_001199276; NM_001271455; NM_001271456; NM_021327
NP_001239314; NP_001239315; NP_001239319; NP_001239320; NP_001239321;
	NP_001239322; NP_001245383; NP_001245384; NP_001245385; NP_006049; NP_001351415; NP_001351416
	NP_001186204; NP_001186205; NP_001258384; NP_001258385; NP_067302
	Wikidata
View/Edit Human	View/Edit Mouse

TNFAIP3-interacting protein 1, also known as ABIN-1, is a protein that in humans is encoded by the TNIP1 gene.^[5]^[6]^[7]

Association with autoimmune diseases

Genetic variations within the region of the TNIP1 gene have been shown to have association with several autoimmune diseases:

TNIP1 dysfunction or deficiency contributes to hyperinflammarion and may predispose healthy cells to the inflammatory response to otherwise innocuous TLR ligand exposure.^[15]

Association with neurodegenerative diseases

A recent genome-wide association study (GWAS) has found that genetic variations in TNIP1 are associated with late-onset sporadic Alzheimer’s disease (LOAD).^[16]

Interactions

TNIP1 contains multiple amino acid sites that are phosphorylated and ubiquitinated,^[17] and has been shown to interact with TNFAIP3,^[18] MAP3K1,^[19] and MAPK1.^[20]

Regulation

TNIP1 was shown to be part of a transcription module controlled by BCL3. BCL3 gen was found to be strongly associated with Aβ42 after conditioning for APOE and was found as upregulated in the brain of patients with LOAD.^[16]