TMA-1 may refer to:

• TMA-1 mine, a circular, plastic-cased Yugoslavian minimum metal anti-tank blast mine
• Soyuz TMA-1, a Russian space exploration mission
• TMA-1 (Tycho Magnetic Anomaly - 1), the fictional Monolith (Space Odyssey) found in the moon's Tycho Crater in the novel and film 2001: A Space Odyssey
• 3,4,5 - Trimethoxyamphetamine (also called TMA), a psychedelic drug

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