TIAL1

TIAL1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTIAL1, TCBP, TIAR, TIA1 cytotoxic granule-associated RNA binding protein-like 1, TIA1 cytotoxic granule associated RNA binding protein like 1
External IDsOMIM: 603413; MGI: 107913; HomoloGene: 87796; GeneCards: TIAL1; OMA:TIAL1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

7073

21843

Ensembl

ENSG00000151923

ENSMUSG00000030846

UniProt

Q01085

P70318

RefSeq (mRNA)

NM_009383
NM_001347640
NM_001347641

RefSeq (protein)

NP_001334569
NP_001334570
NP_033409

Location (UCSC)Chr 10: 119.57 – 119.6 MbChr 7: 128.44 – 128.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleolysin TIAR is a protein that in humans is encoded by the TIAL1 gene.[5][6]

The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been shown to function differently with respect to post-transcriptional silencing.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000151923 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030846 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kawakami A, Tian Q, Duan X, Streuli M, Schlossman SF, Anderson P (Oct 1992). "Identification and functional characterization of a TIA-1-related nucleolysin". Proc Natl Acad Sci U S A. 89 (18): 8681–5. Bibcode:1992PNAS...89.8681K. doi:10.1073/pnas.89.18.8681. PMC 49984. PMID 1326761.
  6. ^ a b "Entrez Gene: TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1".

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q01085 (Nucleolysin TIAR) at the PDBe-KB.
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