THOC1
Protein-coding gene in the species Homo sapiens
THO complex subunit 1 is a protein that in humans is encoded by the THOC1 gene .[ 5] [ 6]
HPR1 is part of the TREX (transcription/export) complex , which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 606390).[supplied by OMIM][ 6]
Interactions
THOC1 has been shown to interact with Retinoblastoma protein .[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000079134 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024287 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondon AG, Aguilera A, Struhl K, Reed R, Hurt E (May 2002). "TREX is a conserved complex coupling transcription with messenger RNA export". Nature . 417 (6886): 304– 8. Bibcode :2002Natur.417..304S . doi :10.1038/nature746 . PMID 11979277 . S2CID 1112194 . ^ a b "Entrez Gene: THOC1 THO complex 1" .^ Durfee, T; Mancini M A; Jones D; Elledge S J; Lee W H (November 1994). "The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing" . J. Cell Biol . 127 (3): 609– 22. doi :10.1083/jcb.127.3.609 . ISSN 0021-9525 . PMC 2120229 PMID 7525595 .
Further reading
Durfee T, Mancini MA, Jones D, et al. (1994). "The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing" . J. Cell Biol . 127 (3): 609– 22. doi :10.1083/jcb.127.3.609 . PMC 2120229 PMID 7525595 . Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1– 2): 171– 4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1– 2): 149– 56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40– 5. doi :10.1038/ng1285 PMID 14702039 . Dennehey BK, Gutches DG, McConkey EH, Krauter KS (2004). "Inversion, duplication, and changes in gene context are associated with human chromosome 18 evolution". Genomics . 83 (3): 493– 501. doi :10.1016/j.ygeno.2003.08.017 . PMID 14962675 . Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130– 5. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 . Gasparri F, Sola F, Locatelli G, Muzio M (2004). "The death domain protein p84N5, but not the short isoform p84N5s, is cell cycle-regulated and shuttles between the nucleus and the cytoplasm". FEBS Lett . 574 (1– 3): 13– 9. doi :10.1016/j.febslet.2004.07.074 . PMID 15358532 . S2CID 43023236 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Li Y, Wang X, Zhang X, Goodrich DW (2005). "Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors" . Mol. Cell. Biol . 25 (10): 4023– 33. doi :10.1128/MCB.25.10.4023-4033.2005 . PMC 1087710 PMID 15870275 . Masuda S, Das R, Cheng H, et al. (2005). "Recruitment of the human TREX complex to mRNA during splicing" . Genes Dev . 19 (13): 1512– 7. doi :10.1101/gad.1302205 . PMC 1172058 PMID 15998806 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173– 8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55– 65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635– 48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Li Y, Lin AW, Zhang X, et al. (2007). "Cancer cells and normal cells differ in their requirements for Thoc1" . Cancer Res . 67 (14): 6657– 64. doi :10.1158/0008-5472.CAN-06-3234 . PMC 2804983 PMID 17638875 . Garner E, Martinon F, Tschopp J, et al. (2007). "Cells with defective p53-p21-pRb pathway are susceptible to apoptosis induced by p84N5 via caspase-6" . Cancer Res . 67 (16): 7631– 7. doi :10.1158/0008-5472.CAN-07-0334 PMID 17699767 .
