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Transforming growth factor beta (TGFβ) receptors are single pass serine/threonine kinase receptors that belong to TGFβ receptor family. They exist in several...

PMID 12015308. Wrighton KH, Lin X, Feng XH (Jul 2008). "Critical regulation of TGFbeta signaling by Hsp90". Proceedings of the National Academy of Sciences of...

The transforming growth factor beta (TGF-β) superfamily is a large group of structurally related cell regulatory proteins that was named after its first...

The transforming growth factor beta (TGFβ) receptors are a family of serine/threonine kinase receptors involved in TGF beta signaling pathway. These receptors...

convertase required for mesoderm induction and the cleavage of specific TGFbeta proteins in Xenopus development". Development. 132 (3): 591–602. doi:10...

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PMID 11792711. Kang Y, Chen CR, Massagué J (April 2003). "A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor...

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and phosphate. Ras is activated by growth factor signaling (i.e., EGF, TGFbeta) and acting as a binary switch (on/off) in growth signaling pathways. Downstream...

MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling". Cell. 89 (7): 1165–73. doi:10...

nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus". Molecular Cell. 10 (2):...

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PMID 8570636. Krishna S, Maduzia LL, Padgett RW (January 1999). "Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated...

PMID 11353865. Krishna S, Maduzia LL, Padgett RW (January 1999). "Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated...

MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling". Cell. 89 (7): 1165–1173. doi:10...

PMC 10216471. PMID 37345088. Vanpouille-Box C, Diamond JM, Pilones KA, et al. TGFbeta is a master regulator of radiation therapy-induced antitumor immunity....

growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling". The...

of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven...

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shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI)". Bioorganic & Medicinal Chemistry Letters. 13...

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homeostasis sequestering of BMP in extracellular matrix sequestering of TGFbeta in extracellular matrix negative regulation of osteoclast differentiation...

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Y, Wrana JL (March 2005). "Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity". Science. 307 (5715): 1603–1609...

component of the TGF-beta receptor-cell complex. Mediates cellular response to TGFbeta. CD106 VCAM-1; Alpha 4 beta 1 ligand. Adhesion molecule involved in white...

matrix Biological process ventricular septum development sequestering of TGFbeta in extracellular matrix coronary vasculature development aorta development...

vessel growth) through causing a switch in transforming growth factor beta (TGFbeta) signaling in endothelial cells. LRG1 binds to the accessory receptor endoglin...

Arthur HM, Mummery CL (December 2004). "Defective paracrine signalling by TGFbeta in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary...

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Massagué J (July 2002). "E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression". Cell. 110 (1): 19–32. doi:10.1016/S0092-8674(02)00801-2...

"Smooth muscle alpha-actin expression and myofibroblast differentiation by TGFbeta are dependent upon MK2". Journal of Cellular Biochemistry. 100 (6): 1581–92...

(February 2001). "Conserved role for 14-3-3epsilon downstream of type I TGFbeta receptors". FEBS Lett. 490 (1–2): 65–9. doi:10.1016/S0014-5793(01)02133-0...

S100C/A11-mediated pathway in resistance of human squamous cancer cell lines to TGFbeta-induced growth suppression". Journal of Molecular Medicine. 85 (7): 753–762...

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Croce CM, Vecchione A (March 2008). "E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer". Cancer Cell...

regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation". Proc. Natl. Acad...

Hocking, R. J.; Atkins, C. J.; Locksley, R. M.; Stockinger, B (2006). "TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation...

Massagué J (Jul 2002). "E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression". Cell. 110 (1): 19–32. doi:10.1016/S0092-8674(02)00801-2...

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PMID 11353865. Krishna S, Maduzia LL, Padgett RW (January 1999). "Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated...

Massagué J (Jul 2002). "E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression". Cell. 110 (1): 19–32. doi:10.1016/s0092-8674(02)00801-2...

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regulator of CTGF expression and cardiac fibrosis. KLF15 inhibits myocardin. TGFbeta mediated activation of p38 MAPK decreases KLF15 permitting the upreg of...

Paris R, Tortosa A, Mora J, Baselga J, Seoane J (February 2007). "High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell...

"Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway". Cell. 125 (5): 929–41. doi:10.1016/j.cell.2006.03.045. PMID 16751102...

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Zhang XH, Wang Q, Nadal C, Gerald WL, Gomis RR, et al. (April 2008). "TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like...

"From genotype to phenotype: the differential expression of FGF, FGFR, and TGFbeta genes characterizes human cranioskeletal development and reflects clinical...

Hocking JC, Hehr CL, Chang RY, Johnston J, McFarlane S (February 2008). "TGFbeta ligands promote the initiation of retinal ganglion cell dendrites in vitro...

PMID 12593671. Lam DS, Lee WS, Leung YF, Tam PO, Fan DS, Fan BJ, Pang CP (2003). "TGFbeta-induced factor: a candidate gene for high myopia". Invest. Ophthalmol....

Chaigne-Delalande, B; Tridon, V; Billottet, C; Reuzeau, E; Génot, E (Dec 1, 2009). "TGFbeta-induced endothelial podosomes mediate basement membrane collagen degradation...

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M, Ohba M, Kuroki T, Namba M, Huh NH (March 2004). "PKCalpha mediates TGFbeta-induced growth inhibition of human keratinocytes via phosphorylation of...

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homologue, Cer1, is associated with the coordinated suppression of the TGFbeta superfamily members Nodal and BMP. This induces Brahma-associated factor...

(Jun 2006). "Evi1 is a survival factor which conveys resistance to both TGFbeta- and taxol-mediated cell death via PI3K/AKT". Oncogene. 25 (25): 3565–75...

"SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling". Nature Cell Biology. 4 (3): 181–190. doi:10.1038/ncb753. PMID 11836524...

April 2010. "Cambridge Antibody, Genzyme to collaborate on human anti-TGFBeta". Drugdiscoveryonline.com. 2 October 2000. Retrieved 12 May 2010. "Genzyme...

Cycle 2004, 3(8):986–9. Michl P, and Downward J. "CUTL1: a key mediator of TGFbeta-induced tumor invasion". Cell Cycle 2006, 5(2):132–4. Sansregret L, and...

PMID 2465299. Hullinger TG, Pan Q, Viswanathan HL, Somerman MJ (January 2001). "TGFbeta and BMP-2 activation of the OPN promoter: roles of smad- and hox-binding...

PMID 12489981. Wrighton KH, Lin X, Feng XH (Jul 2008). "Critical regulation of TGFbeta signaling by Hsp90". Proceedings of the National Academy of Sciences of...

which could be attributed to the downregulation of the ERK1/2, MEK and TGFbeta-1 pathways. Another study demonstrated that adenoviral overexpression of...

stimuli, including induction of TGF-beta signaling. An effector of the TGFbeta receptor, Smad3, may interact directly with APC subunit APC10 and thus...

M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B (February 2006). "TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation...