The club then made their move into the senior pyramid along with nine other SJFA East Region clubs after they were accepted into the East of Scotland League for 2021–22, this time groundsharing at Ochilview Park as part of a strategic partnership with Stenhousemuir.[3] They finished as runners-up in Conference X and gained promotion to the newly formed Second Division for 2022–23.[4]
In June 2022 Syngenta became a full SFA member having gained their club licence, allowing the club to take part in the Scottish Cup and Scottish Youth Cup.[5] However during season 2022–23, Syngenta resigned from the league due to off-field disputes and their results were expunged in March 2023.[6]
^Grimwood, Jez (17 March 2023). "Syngenta FC". Newburgh F.C. Retrieved 17 March 2023. The League table has now been rectified with all Syngenta's results now expunged and the points/goals for all clubs that have played the club now adjusted accordingly.