St Mary's School was established by Sisters of Mercy in 1863 as part of St Mary's Parish for the parish's primary-aged children. In 1913, St Mary's College was established as a separate secondary school exclusively for the higher education of girls in the Mercy tradition. The College and its pupils were now distinct from the Primary School students. The Sisters of Mercy ceased administering and teaching at the school in the early 1990s. The college is owned by the Parish and is now administered and staffed by Brisbane Catholic Education.
Musical and drama productions
Each year, since 2007, a full musical production is conducted, in conjunction with St Edmund's College, Ipswich. The host school alternates every year.
Named after Father Andrew Horan who came to Ipswich in 1875. He was originally meant to fill in at the school's church for Father Brun but ended up staying the rest of his life.
Murphy
Green
Named after Sister Mary Joseph (Bridget) Murphy who worked at the school. With her Irish heritage the house colour is green.