The historic church—located at 515 Cathedral Street in downtown Lafayette—is the third structure built on the site. The land was donated in 1821 by Jean Mouton, a wealthy planter who had founded the town as Vermilionville.[6] The cornerstone was laid in 1913, and the church was completed in 1916 in the Dutch Romanesque Revival style. A large red and white brick structure, its notable features include stained glass produced in Munich depicting the life of the patron, oil paintings of Christ and the Apostles, and a Casavant Frères organ.[4][5]
St. John's Cemetery is the oldest in the city of Lafayette.[7] Notable burials include Jean Mouton, who donated the property for the church; his son Alexandre Mouton, a U.S. senator and governor of Louisiana; his grandson Alfred Mouton, a Confederate general in the American Civil War; and Jefferson Caffery, a distinguished U.S. diplomat who was a Lafayette native.
The church and a 7-acre (2.8 ha) area comprising the Bishop's residence and the cemetery was listed on the National Register of Historic Places on July 27, 1979.[3] The listing was enlarged in 2024.