Sphingomyelin deacylase (EC 3.5.1.109 , SM deacylase , GcSM deacylase , glucosylceramide sphingomyelin deacylase , sphingomyelin glucosylceramide deacylase , SM glucosylceramide GCer deacylase , SM-GCer deacylase , SMGCer deacylase ) is an enzyme with systematic name N-acyl-sphingosylphosphorylcholine amidohydrolase .[ 1] [ 2] [ 3] catalyses the following chemical reaction
(1) an N-acyl-sphingosylphosphorylcholine + H2 O
⇌ ⇌ -->
{\displaystyle \rightleftharpoons }
fatty acid + sphingosylphosphorylcholine ;
(2) a D-glucosyl-N-acylsphingosine + H2 O
⇌ ⇌ -->
{\displaystyle \rightleftharpoons }
The enzyme is involved in the sphingolipid metabolism in the epidermis .
References
^ Hara J, Higuchi K, Okamoto R, Kawashima M, Imokawa G (September 2000). "High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis" . The Journal of Investigative Dermatology . 115 (3): 406–13. doi :10.1046/j.1523-1747.2000.00072.x PMID 10951276 . ^ Higuchi K, Hara J, Okamoto R, Kawashima M, Imokawa G (September 2000). "The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide" . The Biochemical Journal . 350 Pt 3: 747–56. doi :10.1042/0264-6021:3500747 . PMC 1221306 PMID 10970788 . ^ Ishibashi M, Arikawa J, Okamoto R, Kawashima M, Takagi Y, Ohguchi K, Imokawa G (March 2003). "Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis" . Laboratory Investigation; A Journal of Technical Methods and Pathology . 83 (3): 397–408. doi :10.1097/01.lab.0000059931.66821.92 PMID 12649340 .
External links
Activity Regulation Classification Kinetics Types
