Spen may refer to:

• SPEN, human gene
• S.P.E.N., Secret sof
• Spen, West Yorkshire, a location in England
• River Spen, river in West Yorkshire, England, the United Kingdom
• SS Spen, British steamship built in 1908
• Spen Whittaker (1871–1910), English football manager
• SP Energy Networks, the energy networks arm of Scottish Power

• S Pen, stylus pen for Samsung smartphones

This disambiguation page lists articles associated with the title Spen.
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