There are a number of special routes of U.S. Route 85. These special routes connect U.S. Route 85 to downtown areas, bypass city centers or provide alternate routes around an area.
U.S. Route 85 Business in Fort Lupton, Colorado is a business spur that follows SH 52 east from US 85 to Denver Avenue, then turns north onto Denver Ave. and ends at Weld County Road 16 north of town.
U.S. Route 85 Business in Platteville, Colorado is a business spur that goes from the intersection with Weld County Road 28 south of town to US 85 in north Platteville.
U.S. Route 85 Business in Greeley, Colorado is a business route that begins at the Garden City Connector in Evans, Colorado, and runs north into Greeley. At 23rd Street, it joins 8th Avenue and heads north until it terminates at US 85 at the northeast edge of the city.