In 1986 De León was invited to conduct a Papal Mass at St. Peter's, in the Vatican City in Rome; she was the second person, and the first woman, to receive such an invitation.[1] She worked as a conductor of local opera companies, and as a guest conductor in Italy and Mexico.[4]
De León started the Santa Cecilia Orchestra in 1992, using money of her own. Only 12 people attended the orchestra's first concert.[5] The orchestra now numbers 85 paid professional performers.[4] It performs both mainstream classicalrepertoire and works by Latin American composers such as Daniel Catán and Silvestre Revueltas.[6][7] Its two-year music education program, Discovering Music, was started in 1998 and is currently offered in 16 elementary schools throughout Los Angeles.[8]