Small nucleolar RNA SNORD57

Small nucleolar RNA SNORD57
Predicted secondary structure and sequence conservation of SNORD57
Identifiers
SymbolSNORD57
Alt. SymbolsU57
RfamRF00274
Other data
RNA typeGene; snRNA; snoRNA; CD-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

In molecular biology, snoRNA U57 (also known as SNORD57) is a member of the C/D box class of snoRNAs. This family functions to direct site-specific 2'-O-methylation of substrate RNAs.[1]

This snoRNA was originally cloned from human HeLa cells during a screen for intron encoded snoRNAs.[2] It is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) at residue A99 3

References

  1. ^ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. ^ Kiss-László Z, Henry Y, Bachellerie JP, Caizergues-Ferrer M, Kiss T (1996). "Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs". Cell. 85 (7): 1077–88. doi:10.1016/S0092-8674(00)81308-2. PMID 8674114. S2CID 10418885.



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